Marinol is available by prescription in a number of countries, including the United States. It can be used to treat:
- Appetite and weight loss in HIV/AIDS
- Nausea and vomiting in chemotherapy
Marinol has also shown promise in treating the following conditions:
Chronic pain – A small trial found Marinol could alleviate pain in patients with chronic pain of various causes. Treatment with Marinol versus morphine showed similar effectiveness.
MS – A small trial found Marinol could reduce neuropathic pain and improve quality of life in MS patients.
Sleep apnea – A pilot study found Marinol could reduce sleep-disordered breathing in patients with obstructive sleep apnea.
ALS – A pilot study found Marinol could improve sleep and appetite in ALS patients.
Dementia – A small trial found Marinol could reduce disturbed behavior and stimulate weight gain in dementia patients.
Fibromyalgia – A small trial found Marinol could reduce pain in fibromyalgia patients.
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Prasad B, Radulovacki MG, Carley DW (2013). Proof of concept trial of dronabinol in obstructive sleep apnea. Front Psychiatry, 22:1. doi: 10.3389/fpsyt.2013.00001
Schley M, Legler A, Skopp G, Schmelz M, Konrad C, Rukwied R (2006). Delta-9-THC based monotherapy in fibromyalgia patients on experimentally induced pain, axon reflex flare, and pain relief. Curr Med Res Opin, 22:1269-76.
Svendsen Kristina B, Jensen Troels S, Bach Flemming W (2004). Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial BMJ, 329:253. doi: 10.1136/bmj.38149.566979.AE
Volicer, L., Stelly, M., Morris, J., McLaughlin, J. and Volicer, B. J. (1997), Effects of Dronabinol on anorexia and disturbed behavior in patients with Alzheimer’s disease. Int. J. Geriat. Psychiatry, 12: 913–919.