Cesamet is available by prescription in the United States, UK, Canada and Mexico for the treatment of nausea and vomiting related to chemotherapy. It is recommended only for patients who do not respond to conventional treatments.
Cesamet has also shown promise in treating the following conditions:
Neuropathic pain – Small trials found Cesamet could reduce pain and improve quality of life in patients with neuropathic pain of various causes. Treatment with Cesamet was not more effective than dihydrocodeine for neuropathic pain.
Fibromyalgia – Small trials found Cesamet could improve sleep and reduce pain and anxiety in fibromyalgia patients.
PTSD – A small trial found Cesamet could improve sleep and reduce nightmares and daytime flashbacks in PTSD patients.
Spinal cord injury – A small trial found Cesamet could reduce spasticity in spinal cord injury patients.
Frank B, Serpell MG, Hughes J, Matthews JN, Kapur D (2008). Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study. BMJ,336:199. doi: 10.1136/bmj.39429.619653.80
Fraser, G. A. (2009). The use of a synthetic cannabinoid in the management of treatment-resistant nightmares in posttraumatic stress disorder (PTSD). CNS.Neurosci.Ther. 15: 84-88.
Pooyania, S., Ethans, K., Szturm, T., Casey, A. and others. (2010). A randomized, double-blinded, crossover pilot study assessing the effect of nabilone on spasticity in persons with spinal cord injury. Arch.Phys.Med.Rehabil. 91: 703-707.
Skrabek, R. Q., Galimova, L., Ethans, K., and Perry, D. (2008). Nabilone for the treatment of pain in fibromyalgia. J.Pain. 9: 164-173.
Toth, C., Mawani, S., Brady, S., Chan, C. and others. (2012). An enriched-enrolment, randomized withdrawal, flexible-dose, double-blind, placebo-controlled, parallel assignment efficacy study of nabilone as adjuvant in the treatment of diabetic peripheral neuropathic pain. Pain. 153: 2073-2082.
Ware, M. A., Fitzcharles, M. A., Joseph, L., and Shir, Y. (2010). The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial. Anesth.Analg. 110: 604-610.